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Lexicon Pharmaceuticals, Inc.
Drug Names(s): LX3305
Description: LX2931 regulates lymphocytes by inhibiting S1P lyase, the enzyme that degrades S1P. The secreted messenger, S1P, interacts with S1P receptors such as S1P1 to regulate lymphocyte migration from lymphoid tissues (e.g., thymus and spleen).
In preclinical studies, LX2931 produced a consistent reduction in circulating lymphocyte counts in multiple species. In addition, LX2931 reduced joint inflammation and prevented arthritic destruction of joints in mouse models of arthritis.
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