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Tandutinib

Takeda Pharmaceutical Company Ltd

Drug Names(s): MLN0518, MLN518, CT53518

Description: MLN0518 inhibits Flt-3 and platelet-derived growth factor (PDGF) receptor tyrosine kinases (RTK). Approximately 30% of AML patients have a mutation of their Flt-3 gene which may be implicated in the growth and survival of this leukemia. In preclinical studies, MLN518 selectively killed human Flt-3 mutant AML leukemia cells.

Deal Structure: MLN0518 was originally developed by Millennium.

In April 2008, Takeda Pharmaceutical and Millennium Pharmaceuticals announced that they entered into a definitive agreement pursuant to which Takeda will acquire Millennium for approximately $8.8 billion through a cash tender offer of $25.00 per share. The acquisition closed in May 2008.


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