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AEOL 10150

Aeolus Pharmaceuticals, Inc.

Drug Names(s): manganese porphyrin, AEOL-10150

Description: AEOL 10150 is a small molecule, broad-spectrum, catalytic antioxidant specifically designed to neutralize reactive oxygen and nitrogen species. The neutralization of these species reduces oxidative stress, inflammation, and subsequent tissue damage via signaling cascades induced by radiation or chemical exposure. The compound’s mitigation of organ-specific damage induced by acute exposure to potentially lethal doses of radiation and chemical agents is based on the hypothesis, and supporting data, that these stressors initiate a pro-inflammatory cascade that disrupts organ integrity and function in a radiation or chemical dose- and time-dependent fashion. This common mechanism of action permits analysis of efficacy in multiple models of organ-specific damage.

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