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Vintafolide

Endocyte, Inc.

Drug Names(s): EC145, MK-8109, Vynfinit (EU)

Description: EC145 is a folate-targeted chemotherapeutic conjugate (folate vitamin + vinca alkaloid). Vinca agents bind to tubulin and inhibit the replication of dividing cells.

Deal Structure: Merck and Endocyte
In April 2012, Merck and Endocyte entered into an agreement to develop and commercialize vintafolide (EC145).

Under the agreement, Merck will gain worldwide rights to develop and commercialize vintafolide. Endocyte will receive a $120 million upfront payment and is eligible for milestone payments of up to $880 million based on the successful achievement of development, regulatory and commercialization goals for vintafolide for a total of six cancer indications. In addition, if vintafolide receives regulatory approval, Endocyte will receive an equal share of the profit in the United States (U.S.) as well as a double digit percentage royalty on sales of the product in the rest of the world.

Endocyte has retained the right to co-promote vintafolide with Merck in the U.S. and Merck has the exclusive right to promote vintafolide in the rest of world. Endocyte will be responsible for the majority of funding and completion of the PROCEED trial....See full deal structure in Biomedtracker


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