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Sumitomo Dainippon Pharma Co., Ltd.

Drug Names(s): AVE-3933, Radequinil

Description: AC-3933 is a novel cognitive enhancer, with central benzodiazepine receptor (GABA-A receptor) partial inverse agonist properties. AC-3933 suppresses the GABA neurons that inhibit the cholinergic neurons, resulting in the activation of cholinergic neurons. The drug may activate glutamate neurons, as well.

Deal Structure: In August 2003, Dainippon concluded an agreement to license AC-3933 to Aventis. Under this agreement, Aventis will receive the exclusive development and marketing rights of AC-3933 for the world, except Japan, with option rights for China, Taiwan and South Korea. The license to AC-3933 was returned to Dainippon in 2005.

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