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Drug Names(s): rasburicase, SR29142, Fasturtec

Description: ELITEK (rasburicase) is a recombinant urate-oxidase enzyme produced by a genetically modifiedSaccharomyces cerevisiae strain. The cDNA coding for rasburicase was cloned from a strain ofAspergillus flavus. Rasburicase is a tetrameric protein with identical subunits of a molecular mass of about 34 kDa.

Rasburicase catalyses the conversion of uric acid to allantoin. Allantoin is an inactive metabolite of purine metabolism, and is 5 to 10 times more soluble than uric acid, so renal excretion is more effective.

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