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TBC4746

Merck & Co., Inc.

Drug Names(s): TBC4746

Description: TBC4746 is a small molecule integrin antagonist that selectively binds to VLA-4 and prevents the firm attachment of the white blood cells to the vessel wall, thus precluding their migration to the inflammation site.

Deal Structure: In June 30, 2000, Texas Biotechnology Corporation (TBC) enteredinto a worldwide research collaboration and license agreement to discover,develop and commercialize VLA-4 antagonists with Schering-Plough. The primaryfocus of the collaboration will be to discover orally available VLA-4antagonists as treatments for asthma. Under the terms of the agreement,Schering-Plough obtains the exclusive worldwide rights to develop, manufactureand market all compounds from TBC's library of VLA-4 antagonists, as well as therights to a second integrin antagonist. TBC is responsible for optimizing a leadcompound and additional follow-on compounds. Schering-Plough is supportingresearch at TBC and will be responsible for all costs associated with theworldwide product development program and commercialization of the compound. Inaddition to reimbursing research costs, Schering-Plough paid an upfront licensefee and will pay development milestones and royalties on product sales resultingfrom the agreement....See full deal structure in Biomedtracker

Partners: Pfizer Inc.


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