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R(+) Isomer of Zileuton

Chiesi Farmaceutici S.p.A.

Drug Names(s): R(+) Isomer of Zileuton

Description: Zileuton is an orally active inhibitor of 5-lipoxygenase, the enzyme that catalyzes the formation of leukotrienes from arachidonic acid.

R(+) zileuton combined in equal proportion with its mirror image isomer, S(-) zileuton, comprise racemic zileuton, which is the pharmaceutical ingredient in ZYFLO (zileuton tablets) and ZYFLO CR (zileuton) extended-release tablets.

Deal Structure: Cornerstone and Chiesi
In September 2013, Chiesi and Cornerstone announced that the special committee of the Cornerstone Board of Directors, as well as the boards of directors of both companies, have approved a definitive merger agreement under which Chiesi will acquire all of the outstanding common shares of Cornerstone for $9.50 per share in cash. Chiesi currently owns 58% of Cornerstone's outstanding common shares.

In February 2014, Cornerstone Therapeutics announced that its stockholders have approved, at a special stockholder meeting, the previously announced merger agreement, under which Chiesi Farmaceutici S.p.A. (Chiesi) will acquire all of the outstanding common shares of Cornerstone for $9.50 per share in cash.


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