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Drug Names(s): ASP1517, FG-4592, FG4592
Description: FG-4592 is an orally active second generation hypoxia-inducible factor (HIF) prolyl hydroxylase (PH) inhibitor. Inhibition of this enzyme stabilizes HIF, which is involved in erythropoiesis, including the induction of endogenous EPO, the mobilization and utilization of iron stores, and suppression of the inhibitory effects of inflammatory cytokines on erythropoiesis.
In a model of inflammation-induced anemia, FG-4592 reduced abnormally high levels of hepcidin back to normal levels and restored the natural balance in iron regulation. FG-4592 also alleviated microcytosis and hypochromia, typically associated with functional iron deficiency, and corrected anemia in this model.
FibroGen and Yamanouchi
In September 2004, FibroGen entered into an agreement with Yamanouchi Pharmaceutical Co. to license FG-2216. Under this agreement, FibroGen provides Yamanouchi exclusive rights to develop and market FG-2216 and certain other FibroGen compounds with a similar mechanism of action for the treatment of anemia in Japan. FibroGen retains rights in the rest of the world, including North America and Europe. Financial terms of the agreement were not disclosed.
Yamanouchi and Fujisawa
On April 1, 2005, Astellas Pharma was formed from a merger between Yamanouchi Pharmaceutical Co. and Fujisawa Pharmaceutical Co.
FibroGen and Astellas
In April 2006, FibroGen announced it completed an exclusive licensing agreement with Astellas Pharma that provides Astellas rights to certain FibroGen hypoxia-inducible factor (HIF) prolyl hydroxylase (PH) inhibitors for development and marketing for the treatment of anemia in Europe, Commonwealth of...See full deal structure in Biomedtracker
Partners: Astellas Pharma, Inc. FibroGen, Inc.
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