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Ciprofloxacin DPI

Bayer AG

Drug Names(s): inhaled ciprofloxacin, BAY Q3939, BAYQ3939, Cipro Inhaled

Description: Ciprofloxacin dry powder inhaler (DPI) combines ciprofloxacin dry powder that is formulated using Novartis' Proprietary PulmoSphere technology with an easy-to-use delivery inhaler.

Ciprofloxacin is a broad spectrum oral fluoroquinolone that effects a wide range of gram-negative and gram-positive microorganisms. The bactericidal action of ciprofloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination.

Deal Structure: In January 2005, Nektar and Bayer signed a collaboration to develop inhaled Ciprofloxacin. Under the terms of the collaboration, Nektar will be responsible for formulation of the dry powder and development of the inhalation system, as well as clinical and commercial manufacturing of the drug formulation and device combination. Bayer will be responsible for the clinical development and worldwide commercializationof the system. Nektar will receive funding for preclinical development, milestone payments, and royalty payments when and if the product is commercialized.

Partners: Nektar Therapeutics Novartis AG


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