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Valeant Pharmaceuticals International, Inc.

Drug Names(s): Vitragan, hyaluronidase ovine

Description: Vitrase is a sheep derived (ovine) form of hyaluronidase, a group of naturally occurring enzymes that break down hyaluronic acid. Hyaluronic acid is a mucopolysaccharide (a type of carbohydrate) that forms the ground substance between cells in subcutaneous tissue.

Deal Structure: In September 2004, Ista entered into an agreement with Allergan replacing its previous Vitrase collaboration, and reacquired all rights to market and sell Vitrase for all uses in the United States and other specified markets. Under the new agreement, Ista agreed to pay Allergan approximately $10.0 million (paid in full in January 2005). Ista has also agreed to make royalty payments to Allergan on its U.S. sales of Vitrase for use in the posterior region of the eye (no royalties are do for use as a spreading agent). Allergan has an option to commercialize Vitrase in Europe subsequent to European Union product approval. If Allergan does not exercise its option, then such European rights will revert to Ista, and Allergan will be paid a royalty on European sales of Vitrase for use in the posterior region of the eye. Ista has responsibility to file for regulatory approval for Vitrase for vitreous hemorrhage in the EU (there are no plans for development as a spreading agent in...See full deal structure in Biomedtracker

Partners: Otsuka Holdings Co., Ltd. Allergan plc

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