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Merck & Co., Inc.

Drug Names(s): DX-88 (Intravenous), CB-500,929

Description: DX-88 is being developed as a subcutaneous (SQ) formulation for hereditary angioedema (HAE) and as an intravitreal formulation for retinal vein occlusion (RVO).

DX-88 inhibits the protein kallikrein, a molecule involved in blood vessel responses to various stimuli. It plays a role in initiating a cascade of molecular events leading to increased vascular permeability, smooth muscle contraction, vasodilation, and pain.

Deal Structure: In June 2003, Dyax and Genzyme entered into a collaboration for the development of DX-88. Dyax and Genzyme are developing DX-88 for HAE in a 50/50 collaboration -- the two companies are each responsible for 50% of ongoing costs incurred in connection with the development and commercialization of DX-88 for HAE and each will be entitled to receive approximately 50% of any profits realized as a result. Dyax receives potential milestone payments from Genzyme in connection with the development of DX-88. Milestone payments are due upon dosing the first patient in a pivotal clinical trial of DX-88 for HAE, for the first FDA-approved product derived from DX-88, and for additional therapeutic indications developed under the collaboration.

In February 2007, Dyax reached a mutual agreement with Genzyme to terminate their joint venture for the development and commercialization of DX-88 for HAE. The termination agreement stipulates that Dyax will receive all the assets of the joint venture,...See full deal structure in Biomedtracker

Partners: Shire Pharmaceuticals Group PLC

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