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Mitsubishi Tanabe Pharma Corporation

Drug Names(s): MP-513, Tenelia (Japan)

Description: MP-513 is a selective non-cyanopyrroridine dipeptidyl peptidase IV (DPP-IV) inhibitor. DPP-IV is an enzyme that breaks down glucagon-like peptide-1 (GLP-1). GLP-1 binds to receptors on pancreatic beta cells stimulating the release of the hormone insulin. GLP-1 also reduces the secretion of glucagon, a hormone produced by the pancreas that stimulates the liver to convert glycogen to glucose thus increasing blood sugar levels. By delaying the degradation of GLP-1, DPP-IV inhibitors extend the action of insulin while also suppressing the release of glucagon.

MP-513 has a low excretion by the kidneys and long duration of action, which the company hopes to help it differentiate from other DPP-IV inhibitors.

Deal Structure: Mitsubishi Tanabe and Handok
In September 2011, Mitsubishi Tanabe licensed out MP-513 to Handok Pharmaceuticals for the treatment of type 2 diabetes in Korea.

Mitsubishi Tanabe and Daiichi Sankyo
In March 2012, Mitsubishi Tanabe and Daiichi Sankyo agreed to form a strategic sales alliance to conduct joint sales activities for MP-513 (teneligliptin) and TA-7284 (canagliflozin) in Japan for the treatment of type 2 diabetes mellitus.

Partners: Daiichi Sankyo Co., Ltd. Handok Pharmaceuticals, Inc.

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