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AVP-13358

Otsuka Holdings Co., Ltd.

Drug Names(s): AVP-13358

Description: AVP 13358 is intended to inhibit the production of IgE antibodies. In addition to its effect on IgE, this compound has demonstrated an ability to suppress the antigen-stimulated IL-4 and IL-5responses with potencies similar to those observed for IgE suppression. AVP 13358 also suppresses markers of disease in mouse models of asthma, including pulmonary lavage levels of IL-4, IL-5, eosinophils, and lymphocytes, as wellas expression of CD23 and the IL-4 receptor (IL-4Ralpha) on leukocytes. AVP 13358 is orally active and appears to be selective for the suppression of Th2 cytokine-mediated diseases.

Deal Structure: Avanir and Otsuka
In December 2014, Avanir entered into a definitive agreement with Otsuka pursuant to which Otsuka will acquire Avanir for $17.00 per share in cash. The transaction, which values Avanir at approximately $3.5 billion, has been unanimously approved by the boards of directors of both companies.

In January 2015, Otsuka announced that it has successfully completed its acquisition of Avanir.


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