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Vertex Pharmaceuticals Incorporated

Drug Names(s): VX-765

Description: VX-765 is an oral interleukin-1 beta converting enzyme (ICE, also called caspase-1) inhibitor.

Interleukin-1 is a cytokine involved in various immune responses, inflammatory processes, and the formation of blood cellular components.

In addition, there is increased IL-1 expression in the brain tissue from epilepsy patients and animal models after seizures, and IL-1 has proconvulsive properties when applied exogeneously. However, there have been opposing results found as well, so its role in seizure generation is still unclear.

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