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Celldex Therapeutics, Inc.

Drug Names(s): CR002

Description: CR002 is a fully human monoclonal antibody, generated with Abgenix's XenoMouse(R) technology, which neutralizes PDGF-D, a mediator discovered by CuraGen that stimulates mesangial cell proliferation. Mesangial cell proliferation has been implicated in the pathogenesis of IgA nephropathy, lupus nephritis, and diabetic nephropathy, forms of kidney inflammation that can lead to kidney failure.

Deal Structure: CR002 was originally developed by CuraGen.

In May 2009, Celldex Therapeutics announced it entered into a definitive agreement to acquire CuraGen. In October 2009, Celldex Therapeutics announced the successful completion of its acquisition of CuraGen Corporation.

Partners: Amgen, Inc.

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