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Suven Life Sciences Ltd

Drug Names(s): SUVN-502

Description: SUVN-502 is a selective, orally active 5-HT6 receptor antagonist. Preclinical data suggests that the 5-HT6 receptor is found mainly in the central nervous system with little or no expression in peripheral tissues, which may result in greater drug selectivity with fewer side effects. Some areas the 5-HT6 receptor is found in are important for learning and memory. In preclinical models, blockade of the receptor improves cognitive function, and also reduces signs thought to reflect anxiety and depression. Blockade is accompanied by enhancement of cholinergic, glutamatergic, noradrenergic, and dopaminergic neurotransmission, together with learning-associated neuronal remodeling. The receptor may also be involved in food intake.

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