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Entolimod

Cleveland BioLabs, Inc.

Drug Names(s): Protectan CBLB502, SA-702 Vaccine Adjuvant

Description: Protectan CBLB502 is recombinant derivative of the bacterial protein, flagellin, which binds and activates the mammalian TLR5 cell surface receptor. CBLB502 mobilizes several tissue protective mechanisms, including inhibition of programmed cell death (apoptosis), reduction of oxidative damage and induction of regeneration-promoting cytokines.

Deal Structure: Cleveland and Roswell Park
In January 2007, Cleveland BioLabs announced that it has entered into a strategic research partnership with Roswell Park Cancer Institute to develop the Company's cancer and radio-protectant drug candidates.

Roswell Park and various agencies of the state of New York will provide Cleveland BioLabs with up to $5 million of non-dilutive funding. Cleveland BioLabs will establish a major research/clinical facility at the Roswell Park campus. The Company will have an open-ended license to any basic research conducted within or in collaboration with its Roswell Park laboratory.


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