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Boehringer Ingelheim GmbH
Drug Names(s): BI 2536
Description: BI 2536 is a small molecule, ATP-competitive kinase inhibitor that is a derivative of dihydropteridinone. BI 2536 acts by binding to and inhibiting Polo-like kinase 1 (Plk1), resulting in mitotic arrest, disruption of cytokinesis, and apoptosis in susceptible tumor cell populations. Plk1, a serine/threonine-protein kinase, is a key regulator of multiple processes fundamental to mitosis and cell division.
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