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Novartis AG

Drug Names(s): CSL-123, HCV Vaccine (w/CSL Ltd.), ISCOMATRIX

Description: CSL-123 is a vaccine based on the recombinant HCV core antigen and CSL's ISCOMATRIX adjuvant to prime Tc1-like CTL response, for the potential treatment of hepatitis C virus (HCV) infection.

Deal Structure: CSL-123 was originally developed by Chiron.

In January 2004, Chiron announced a new collaboration agreement with CSL Limited to develop a therapeutic hepatitis C vaccine. Under the terms of the joint development agreement, Chiron will provide its novel hepatitis C virus (HCV) antigens, and CSL will contribute its proprietary ISCOMATRIX adjuvant technology.

In April 2006, Novartis announced that shareholders of Chiron Corporation voted to approve its acquisition of Chiron. Under the terms of the transaction, which closed on April 20, Novartis acquired all outstanding shares of Chiron that Novartis does not already own for USD 48 per share. The all-cash deal represents a total value of USD 5.4 billion.

Partners: CSL Limited

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