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Dexelvucitabine

Incyte Corporation

Drug Names(s): Reverset, RVT, D-D4FC, DPC-817

Description: Reverset, a nucleoside analog that targets the HIV-1 reverse transcriptase enzyme, is being developed under an approved US FDA Investigational New Drug (IND) application for the treatment of HIV-infected individuals. Preclinical in vitro studies have shown that Reverset inhibits replication of drug-resistant HIV strains commonly seen after treatment with zidovudine (ZDV) and lamivudine (3TC).

Deal Structure: Pharmasset and Incyte announced a collaborative license agreement in September 2003 to develop and commercialize Reverset. Pharmasset will receive from Incyte future performance milestone payments and royalties on net sales in exchange for exclusive rights in the U.S., Europe and certain other markets to develop, manufacture and market the drug. Pharmasset retained development, marketing and commercialization rights in certain territories, including Mexico, Central and South America, Africa, the Middle East, Korea and China.

In November 2011, Gilead and Pharmasset announced that the companies have signed a definitive agreement under which Gilead will acquire Pharmasset for $137 per share in cash. The transaction values Pharmasset at approximately $11 billion. In January 2012, Gilead announced the successful completion of the tender offer for all of the outstanding shares of common stock of Pharmasset.

Partners: Gilead Sciences, Inc.


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