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Drug Names(s): eliglustat, GENZ-112638
Description: GENZ 112638 is a ceramide analog given as an oral capsule. It is designed to inhibit the enzyme glucosylceramide synthase, which results in reduced production of glucocerebroside, a substance that builds up in patients with Gaucher disease. The pathway is also involved in Tay-Sachs, Sandhoff, and Fabry diseases.
Genzyme originally licensed eliglustat from the University of Michigan.
Genzyme and Sanofi
In October 2010, Sanofi-aventis announced it has commenced a tender offer for all outstanding shares of common stock of Genzyme for $69 per share, net to the seller in cash, without interest and less any required withholding taxes. In April 2011, Sanofi-aventis announced that it successfully completed its exchange offer for all outstanding shares of common stock of Genzyme Corporation.
PDL and University of Michigan
In November 2014, acquired a portion of the University of Michigan's worldwide royalty interest in Cerdelga for $65.6 million. Under the terms of the royalty agreement, PDL will receive 75 percent of all royalty payments due under U-M's license agreement with Genzyme until expiration of the licensed patents, excluding any patent term extension. The royalty rate used to calculate the royalties to be paid by Genzyme to U-M was not disclosed by the...See full deal structure in Biomedtracker
Partners: PDL BioPharma, Inc. University of Michigan
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