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Motif Bio plc
Drug Names(s): AR-100, Ro 48-2622, Mersarex
BioMedTracker has separate drug entries for the oral and IV formulations of Iclaprim. Please also see Iclaprim (Oral).
Iclaprim is a novel diaminopyrimidine, specific and selective inhibitor of microbial dihydrofolate reductase (DHFR). It has demonstrated potent activity against a broad spectrum of Gram-positive bacteria, including MRSA (methicillin-resistant Staphylococcus aureus) and S.aureus that exhibit reduced susceptibility (VISA) and resistance (VRSA) to standard of cure therapy vancomycin. It is also active against several important Gram-negative and intracellular pathogens. Iclaprim is rapidly bactericidal and therefore is able to actively kill pathogens, rather than just stopping their growth. Furthermore, it penetrates well into tissues that often harbor difficult to treat bacterial pathogens.
Roche and Arpida
In November 2001, Roche and Arpida have entered into a sales and purchase agreement where Arpida will receive exclusive world-wide rights for the development and commercialisation of Iclaprim. Under the terms of the agreement, all patent rights will be transferred to Arpida. Consequently, Arpida shall have exclusive world-wide commercialisation rights and will be responsible for future development and clinical registration. In exchange, Roche will receive a consideration based on future sales.
Arpida and Evolva
In September 2009, Arpida and Evolva announced that the Companies intend to merge subject to definitive agreement and shareholder approval. The merger closed in December 2009.
Motif and Undiclosed Company
In January 2015, Amphion announced that its partner company, Motif, has entered into an agreement to merge with a private company that holds the intellectual property and world-wide rights to a clinical stage...See full deal structure in Biomedtracker
Iclaprim (IV) News
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