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Drug Names(s): LX4211
Description: LX4211 is an orally-delivered small molecule under development as a potential treatment for diabetes. LX4211 inhibits both sodium-glucose co-transporter type 1 (SGLT1) and sodium-glucose co-transporter type 2 (SGLT2). SGLT2 is a transporter responsible for most of the glucose reabsorption performed by the kidney. SGLT1 is a transporter responsible for glucose and galactose absorption in the gastrointestinal tract, and to a lesser extent than SGLT2, glucose reabsorption in the kidney.
Percentage revenue splits for Sanofi and Lexicon are a BioMedTracker estimates.
Lexicon and Sanofi
In November 2015, Sanofi and Lexicon entered into a collaboration and license agreement for the development and commercialization of sotagliflozin, which could be a potential treatment option for people with diabetes. Under the terms of the agreement, Lexicon will receive an upfront payment of $300 million and is eligible to receive development, regulatory and sales milestone payments of up to $1.4 billion. Lexicon is also entitled to tiered, escalating double digit percentage royalties on net sales of sotagliflozin.
Sanofi obtains an exclusive worldwide license to develop, manufacture and commercialize sotagliflozin. Lexicon will continue to be responsible for all clinical development activities relating to type 1 diabetes and will retain an exclusive option to co-promote and have a significant role, in collaboration with Sanofi, in the...See full deal structure in Biomedtracker
Partners: Lexicon Pharmaceuticals, Inc.
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