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PBT-1

Prana Biotechnology

Drug Names(s): Clioquinol

Description: PBT-1 is a copper/zinc-binding drug. In preclinical studies, PBT-1 markedly reduced Alzheimer brain pathology in mice within nine weeks. Beta-amyloid accumulation decreased by 50% during that period. This breakthrough provides a viable explanation for the abnormal binding of these metals with beta-amyloid that is commonplace in Alzheimer's disease. The reaction ultimately leads to the corruption of the protein and its ensuing toxicity. Copper and Zinc are normally present at high concentrations in the regions of the brain that are most affected by Alzheimer's disease damage.


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