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LY2428757

Eli Lilly & Company

Drug Names(s): GLP1-PEG

Description: LY2428757 is a pegylated once-weekly GLP1 analogue.

GLP-1 is an incretin hormone secreted in the small intestine and colon in response to food intake. It enhances insulin secretion when glucose levels are high, suppresses inappropriate glucagons secretion (glucagon has the opposite effect of insulin), slows gastric emptying (slowing entry of ingested nutrients into the bloodstream, hence limiting post-prandial glucose), and via actions on the brain is thought to promote satiety.


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