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Zealand Pharma A/S

Drug Names(s): ZP1848, ZP 1848, ZP-1848, Glepaglutide

Description: ZP1848 is a Glucagon-Like Peptide-2 agonist which incorporates Zealand'sproprietary SIP-technology. One of the aims of the SIP-technology (Structure-Inducing Probe technology) is to optimize the therapeutic profile of a broad range of active peptides (e.g., increased efficacy, increased drug stability, and increased persistence in the human body).

Glucagon-like Peptide-2 (GLP-2) is a naturally occurring peptide hormone,secreted by the small intestine. GLP-2 binds to and acts exclusively via the GLP-2 receptor, expressed primarily in the gastrointestinal tract. GLP-2 has beenshown to have numerous beneficial effects in the small intestine. These includestimulation of the growth of the small intestinal lining, enhancement of nutrientdigestion and absorption, and reinforcement of the intestinal barrier function.Moreover, GLP-2 has been shown to decrease inflammation, and to enhanceanimal survival in a broad range of preclinical models of gut injury including,models of Inflammatory Bowel Disease.

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