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Merck & Co., Inc.

Drug Names(s): MK-4305, MK4305, Suvorexant

Description: MK-4305 is a dual orexin receptor antagonist, inhibiting the actions of the neuropeptides orexin A and orexin B, which bind with the OX1R and OX2R receptors (OX1R binds orexin A, and OX2R binds both). These neuropeptides are produced by neurons in the hypothalamus, and play a key role in regulation of the brain's sleep-wake process. Orexin antagonists are thought to block the stimulation of the brain's arousal system.

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