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Merck & Co., Inc.

Drug Names(s): montelukast sodium, Kipres, MK0476

Description: Singulair (Montelukast) is a selective and orally active leukotriene receptor antagonist that inhibits the cysteinyl leukotriene CysLT1 receptor.

The cysteinyl leukotrienes are products of arachidonic acid metabolism and are released from various cells including eosinophils and mast cells. These eicosanoids bind to cysteinyl leukotriene (CysLT) receptors. The CysLT type-1 (CysLT1) receptor is found on human airway and proinflammatory cells and its activation correlates with asthma and allergic rhinitis.

Partners: Kyorin Pharmaceutical Co., Ltd.

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