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LE-DT

INSYS Therapeutics, Inc.

Drug Names(s): Liposome Encapsulated Docetaxel

Description: LE-DT is a novel, proprietary liposomal delivery system of docetaxel, the active ingredient of Taxotere. Taxotere (Docetaxel) is derived from the needles of the European yew tree. It belongs to the taxane class of chemotherapy drugs that inhibits tumor cell proliferation by disrupting the normal process of microtubule assembly and disassembly.

Microtubules are cylindrical structures that form the basis of the cellular skeleton and are essential to the reproduction, growth, and spread of tumor cells. Normally, as a part of the mitotic process, microtubules are reorganized to form a spindle. Taxotere binds tubulin, promoting polymerization and preventing de-polymerization of microtubules. Thus, it stabilizes microtubules which causes cell death.


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