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ETC-1002

Esperion Therapeutics, Inc.

Drug Names(s): ETC1002, bempedoic acid

Description: ETC-1002 is an oral small molecule that inhibits fatty acid and cholesterol synthesis, and also enhances oxidation of fatty acids. It is believed to work by inhibiting ATP citrate lyase (ACL)--which is part of the cholesterol-synthesis pathway, a couple of steps upstream from the enzyme inhibited by statins--and interacting with acyl-CoA synthase to increase the AMP/ATP ratio, which the company believes activates AMP-kinase. The company believes the drug also directly activates AMP-kinase, though the precise mechanism is unclear.

Deal Structure: In December 2003, Esperion was acquired by Pfizer. In May 2008, Pfizer sold Esperion to an entity funded by a syndicate of investors. Pfizer has an equity stake in the new Esperion.


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