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Drug Names(s): PM00104

Description: PM00104 is a novel synthetic alkaloid related to the marine compounds jorumycin and renieramycins.

Preliminary preclinical studies suggest changes in cell cycle and DNA binding properties and transcriptional inhibition as main mechanisms of action. PM00104 has shown broad in vitro and in vivo anti-tumor activity (IC50 <10-8 M) with an acceptable toxicology profile.

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