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Imgatuzumab

Roche Holding AG

Drug Names(s): GA201, RO5083945, RG7160

Description: The anti-EGFR MAb GA201 is a recombinant, humanized, and glycoengineered MAb ofthe immunoglobulin G1 (IgG1) subclass directed against EGFR/HER1. GA201 hasdemonstrated high-affinity binding to EGFR with inhibition of EGF ligand binding, EGFR/HER2heterodimerization, EGFR downstream signaling and cell proliferation, and induction of celldeath. In addition, GA201 was engineered for high ADCC potency. In preclinical models,GA201 has demonstrated greater activity than other anti-EGFR antibodies.

Deal Structure: GA201 was originally developed by GlycArt.

In July 2005, Roche announced that it signed an agreement to acquire 100% of GlycArt.


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