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Wilex AG

Drug Names(s): WX554

Description: WX-554 is an orally available, small-molecule Mitogen-activated protein kinase (MEK) inhibitor. MEK has been shown to play a central role in signal transduction. MEK has been linked to a multitude of biological processes such as cell division, cell differentiation and cell death. The MEK signalling pathway is overexpressed in more than 30% of cancers, resulting in uncontrolled cell growth and proliferation.

Deal Structure: In January 2009, UCB Pharma WILEX announced that they agreed to enter into a strategic partnership. WILEX will acquire world-wide rights to develop UCB's entire preclinical oncology portfolio, comprising two small-molecule programmes and three antibody programmes, of which WX-554 is included.

UCB retains exclusive rights to re-purchase each of the five programmes, following completion of initial clinical feasibility studies for each programme, and assume the responsibility for further development and commercialization of each product. In this case, WILEX will receive development and commercialisation milestone payments and royalty payments from UCB.

Alternatively, in the event UCB does not exercise its re-purchase right for each programme, WILEX will retain rights to develop as well as commercialize each programme and UCB will receive milestone and royalty payments from WILEX.

Upon the first dose in man, a second milestone payment of EUR 5 million agreed in the strategic...See full deal structure in Biomedtracker

Partners: UCB SA

WX-554 News

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