This web site is part of the Business Intelligence Division of Informa PLC

This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC’s registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726.

MDCO-2010

The Medicines Company

Drug Names(s): CU2010

Description: CU2010 is an antifibrinolytic agent designed to limit blood loss during surgery. CU-2010 has a high affinity for and inhibits plasmin (Ki, 2 nM), to prevent break up of fibrin clots, and also inhibits coagulation factors Xa (Ki, 45 nM) and XIa (Ki, 18nM). It also has a high affinity for and inhibits plasma kallikrein (Ki < 1 nM), which is thought to be involved in leakage of fluid from the blood vessels into the tissues during on-pump cardiothoracic surgery (where blood is rerouted through a separate cardiopulmonary bypass machine). In preclinical studies, CU2010 has demonstrated a pharmacokinetic profile in the surgical setting with a rapid onset and offset of effect, due to its short half life.

Deal Structure: CU2010 was acquired by The Medicines Company through the acquisition of Curacyte Discovery GmbH in August 2008.


MDCO-2010 News


Additional information available to subscribers only:

  • Targets
  • Routes
  • Catalysts
  • Designations
  • Events

Request a Free Demo Subscriber Login Search for another drug