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Drug Names(s): Spiegelmer NOX-A12

Description: NOX-A12 mobilizes hematopoietic stem cells from the bone marrow by disrupting the Stromal Cell-Derived Factor-1 (SDF-1, alsoknown as CXCL12) gradient that normally attracts them to their niches. Studies in animal models demonstrate that treatment with a single dose of Spiegelmer NOX-A12 significantly mobilizes hematopoietic progenitor cells in a dose dependent manner.

Spiegelmers (L-aptamers) are chemical entities based on synthetic mirror-imageoligonucleotides which are highly selective for their pharmacological target and potent inhibitors of target function.

NOX-A12 News

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