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Eisai Co., Ltd.
Drug Names(s): E2212
Description: E2212 is a gamma secretase modulator. Gamma secretase is involved in the production of beta-amyloid, the major component of amyloid plaques seen in Alzheimer's disease. In preclinical studies, E2212 exhibited a more potent inhibition of the formation of amyloid beta (Aß42) by gamma secretase, apparently without impacting Notch-processing, a key process in normal cell differentiation that is also processed by gamma secretase.
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