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Nepicastat

Biotie Therapies Corp.

Drug Names(s): SYN117, SYN-117

Description: SYN-117 is a competitive and selective inhibitor of the enzyme dopamine beta-hydroxylase (DBH). Inhibition increased dopamine in the central nervous system. Of note, one study has found DBH activity higher in patients with post-traumatic stress disorder with psychotic features than with non-psychotic features.

Deal Structure: SYN-117 was originally developed by Roche.

Roche and Synosia
In January 2007, Roche and Synosia entered a partnership in which Synosia will acquire five drug candidates from Roche, including SYN-117. Under the terms of the agreement, Synosia will assume responsibility for the clinical development of the five drug candidates, including SYN-117. Roche retains the right to opt-in to potential products resulting from two of these programs on completion of agreed milestones. Synosia retains full commercial rights to three pre-selected programs and can bring these products to market either alone or with a partner.

In March 2009, Synosia announced it has entered into a second agreement with Roche, extending the partnership to include a second 5-HT6 antagonist and also revising the terms of the original agreement to give Synosia full development and commercialisation rights to all programmes. Roche retains opt-in rights to the 5-HT6 programme only.

Biotie and...See full deal structure in Biomedtracker


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