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BMS-741672

Bristol-Myers Squibb Company

Drug Names(s): BMS-741672

Description: BMS-741672 is an oral, CCR2 antagonist. CCR2 is a receptor for various monocyte chemoattractant proteins, which are involved in the inflammatory process. Chronic inflammation in adipose tissue may play a role in insulin resistance associated with obesity, and monocyte chemoattractant protein 1 (MCP-1) is increased in adipose tissue and the circulation in association with obesity. In a preclinical study (unrelated to this particular drug), chronic increases in circulating MCP-1 induced insulin resistance, macrophage infiltration into adipose tissue, and an increase in hepatic triacylglycerol content.


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