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Nuon Therapeutics, Inc.
Drug Names(s): tranilast and allopurinol
Description: NU1618 is a combination of tranilast and allopurinol. Allopurinol reduces the production or uric acid through inhibition of the enzyme xanthine oxidase. The company says that tranilast inhibits uric acid transport by both URAT1 and GLUT9, transporters in the kidney that regulate uric acid excretion from the body. Tranilast has anti-inflammatory properties and inhibits collagen synthesis, so is approved for asthma and keloid/scars in Japan. As an immune system modulator, it may address the chronic inflammatory component of gout.
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