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FIT GTU HIV vaccine

FIT Biotech Oy

Drug Names(s): GTU-MultiHIV B clade, FIT-06

Description: FIT-06 is a DNA-based therapeutic vaccine based on FIT Biotech's proprietary GTU (Gene Transport Unit) technology. FIT-06 involves a plasmid containing the regulatory HIV-1 proteins Rev, Nef, and Tat, as well as Gag p17/p24 and a stretch of cytotoxic T lymphocyte (CTL) epitope clusters from pol and env of a subtype B-HIV-1 Han-2 isolate. The plasmid also contains a nuclear anchoring protein (bovine papilloma virus E2) to ensure the long maintenance of the vector and a high expression level of the selected immunogens.

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