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GRC 17536

Glenmark Pharmaceuticals Limited

Drug Names(s): GRC 17536

Description: GRC 17536 is a TRPA1 receptor antagonist. It reversed hyperalgesia in in vivo models of Freund’s complete adjuvant induced inflammatory and chronic constriction injury (CCI) induced neuropathic pain with an EC50 of less than 10 mg/kg. In addition, when tested in an in vivo model of asthma, it showed efficacy in airway inflammation, bronchoconstriction and cough.

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