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Novo Nordisk A/S
Drug Names(s): long-acting rFVIIa derivative, rFVIIa glycopegylated, N7-GP (Subcutaneous)
Description: NN7129 is a glyco-PEGylated derivative of recombinant human factor VII (rFVIIa) for subcutaneous administration.
The main role of FVII is to initiate the process of coagulation in conjunction with tissue factor (TF). Tissue factor is found on the outside of blood vessels - normally not exposed to the bloodstream. Upon vessel injury, tissue factor is exposed to the blood and circulating factor VII. Once bound to TF, FVII is activated to FVIIa by different proteases, among which are thrombin (factor IIa), activated factor X and the FVIIa-TF complex itself. The most important substrates for FVIIa-TF are Factor X and Factor IX.
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