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Forward Pharma A/S

Drug Names(s): dimethyl fumarate, BG00012

Description: FP187 is a formulation of dimethyl fumarate (DMF), an oral small molecule that has been used to treat psoriasis since the 1950's. DMF inhibits NFkappaB translocation, which leads to (i) the inhibition of pro-inflammatory cytokine production and adhesion molecule expression, (ii) the inhibition of dendritic cell differentiation and, at higher concentrations, and (iii) the induction of apoptosis.

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