This web site is part of the Business Intelligence Division of Informa PLC

This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC’s registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726.


Noscira SA

Drug Names(s): NP031112, NP-12, tideglusib

Description: BioMedTracker has separate drug profiles for NP-12. Please also see Nypta, the tradename for the drug in Alzheimer's disease.

NP-12, a thiadiazolidinone, is a selective (non ATP-competitive) inhibitor of glycogen synthase kinase 3ß (GSK3ß). In addition to be involved in the processes of cellular signaling of insulin and IGF-1, GSK3ß is highly expressed in the brain, with evidence that it is involved in the hyperphosphorylation of tau protein and increased amyloid beta production, which respectively form the hallmark neurofibrillary tangles and plaques in Alzheimer's disease.

Zentylor News

Additional information available to subscribers only:

  • Targets
  • Routes
  • Catalysts
  • Designations
  • Events

Request a Free Demo Subscriber Login Search for another drug