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Drug Names(s): VWF/FVIII concentrate, Biostate

Description: Biostate is a freeze-dried preparation containing human coagulation factor VIII, a protein which is essential for normal blood clotting. It is a low-volume, highly active, plasma-derived VWF/FVIII concentrate. It contains high molecular weight multimers of VWF. Biostate has a VWF to FVIII ratio of approximately 2.2 to 1.

VWF binds to FVIII and keeps it stable. Upon activation by thrombin, the complex dissociates, and factor FVIII, in conjunction with FIX, activates FX.

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