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Pfizer Inc.

Drug Names(s): linezolid

Description: Linezolid is a synthetic antibiotic belongingto a new class of antimicrobials called the oxazolidinones.Linezolid disrupts bacterialgrowth by inhibiting the initiation process inprotein synthesis. This site of inhibitionoccurs earlier in the initiation process thanother protein synthesis inhibitors (e.g., chlo-ramphenicol [Chloromycetin],clindamycin[Cleocin], aminoglycosides, and macrolides)that interfere with the elongation process.Because the site of inhibition is unique to linezolid,cross-resistance to other protein synthesisinhibitors has not yet been reported.Linezolid may also inhibit virulence factorexpression and decrease toxin production ingram-positive pathogens.

Linezolid exhibits good activity against methicillin-sensitive and -resistant S. aureus, streptococci (including multidrug resistant S. pneumoniae), enterococci (including VRE) and Nocardia; moderate activity against certain atypicals; and poor activity against Gram-(-) bacteria and anaerobes.

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