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NSI-189

Neuralstem Inc.

Drug Names(s): NSI-189

Description: NS-189 is the first in a class of compounds that Neuralstem plans to develop into orally administered drugs. These appear to have the effect of recruiting the patient's own neural stem cells to repair or protect against damage to the Central Nervous System (CNS) from disease or injury.

NSI-189 stimulated neurogenesis of human hippocampus-derived neural stem cells in-vitro. In mice, NSI-189 both stimulated neurogenesis of the hippocampus and increased its overall volume. Therefore, NSI-189 may reverse the human hippocampal atrophy seen in major depression and schizophrenia.

Deal Structure: In June 2011, Neuralstem announced that it has signed an exclusive agency licensing agreement with Summit Pharmaceuticals International Corporation, of Tokyo, Japan (SPI), a wholly owned subsidiary of Sumitomo Corporation Group. Under the agreement, SPI will market development and licensing rights to NSI-189 in Japan.

Partners: Summit Pharmaceuticals International


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