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Fosamax (and Fosamax Plus D)

Merck & Co., Inc.

Drug Names(s): Alendronate sodium (and alendronate sodium/cholecalciferol); Adrovance (France); Fosavance (EU); Bonalon (Japan), MK-0217, Fosamac, Vantavo

Description: Fosamax is a bisphosphonate that inhibits osteoclast-mediated bone resorption and modulates bone metabolism. Thus, it reduces bone turnover, improves bone mineralization, and increases bone mass. It is taken daily or weekly.

Fosamax Plus D includes cholecalciferol (vitamin D3), which after conversion to 1,25-dihydroxyvitamin D3 increases intestinal absorption of both calcium and phosphate, and is involved in the regulation of serum calcium, renalcalcium and phosphate excretion, bone formation and bone resorption.

Deal Structure: Revenue splits for this drug are BMT estimates.

In January 2007, Ipsen and Merck Sharp & Dohme (MSD), announced the signing of a co-marketing agreement under which MSD will grant Ipsen themarketing rights in France for Adrovance. Under the terms of the agreement, Ipsen will source the product from MSD, market and sell itunder the brand name Adrovance in France.

Partners: Ipsen SA Teijin Pharma Limited

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