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Drug Names(s): J867
Description: Asoprisnil is a novel selective steroid receptor modulator. Its major metabolite is J912, and other structurally related compounds represent a new class of progesterone receptor (PR) ligands that exhibit partial agonist and antagonist activities in vivo. Asoprisnil demonstrates a high degree of receptor and tissue selectivity, with high-binding affinity for PR, moderate affinity for glucocorticoid receptor (GR), low affinity for androgen receptor (AR), and no binding affinity for estrogen or mineralocorticoid receptors.
Deal Structure: Asoprisnil was originally developed by EnTec (a subsidiary of Jenapharm; Schering) and later developed by TAP Pharmaceutical Products.
In 2006, Bayer acquired Schering AG.
In March 2008, Takeda Pharmaceutical and Abbott concluded their TAP Pharmaceutical Products joint venture.
Partners: Bayer AG
Pink Sheet British Approved Names
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